Molday and Hsu review results from in vitro experiments, which indicate that Ca-bound calmodulin reduces the cGMP sensitivity of the cyclic nucleotide-gated channel of photoreceptor cells, and speculate about the role they might play in the recovery of the light response. We discuss results from in vivo experiments that argue against the participation of Ca-calmodulin in photorecovery.

This paper presents arguments and evidence from psychology and neuroscience supporting Lipton’s 2004 claim that scientists create knowledge through an abductive process that he calls “Inference to the Best Explanation”. The paper develops two conclusions. Conclusion 1 is that without conscious effort on our part, our brains use a process very similar to abduction as a powerful way of interpreting sensory information. To support Conclusion 1, evidence from psychology and neuroscience is presented that suggests that what we humans perceive through (...) our senses is not reality, but rather, our ‘brain’s “best guess” of the causes of its sensory input. The implication of this best guessing is that our brains use a process very similar to abduction throughout our lives to inform us of what is happening in the world around us. In addition, an argument based on Darwinian evolution is presented claiming that our brains do an excellent job of interpreting sensory information from the outside world. (If they did not, we, as a species, could hardly have survived.) Combining these two claims leads to Conclusion 1. Building on Conclusion 1, Conclusion 2 is that Lipton and others are correct in claiming that scientists use abduction when creating scientific theories. Abduction must be strong, because Nature chose abduction for its own sensemaking purposes. This paper’s contribution to knowledge is in pointing out that recent psychological and neuroscientific research has major implications for the philosophical world’s confidence in the probable validity of abductive inference. The punchline is simple: Nature chose abduction! (shrink)

I defend the following version of the ought-implies-can principle: (OIC) by virtue of conceptual necessity, an agent at a given time has an (objective, pro tanto) obligation to do only what the agent at that time has the ability and opportunity to do. In short, obligations correspond to ability plus opportunity. My argument has three premises: (1) obligations correspond to reasons for action; (2) reasons for action correspond to potential actions; (3) potential actions correspond to ability plus opportunity. In the (...) bulk of the paper I address six objections to OIC: three objections based on putative counterexamples, and three objections based on arguments to the effect that OIC conflicts with the is/ought thesis, the possibility of hard determinism, and the denial of the Principle of Alternate Possibilities. (shrink)

Imperatives cannot be true or false, so they are shunned by logicians. And yet imperatives can be combined by logical connectives: "kiss me and hug me" is the conjunction of "kiss me" with "hug me". This example may suggest that declarative and imperative logic are isomorphic: just as the conjunction of two declaratives is true exactly if both conjuncts are true, the conjunction of two imperatives is satisfied exactly if both conjuncts are satisfied—what more is there to say? Much more, (...) I argue. "If you love me, kiss me", a conditional imperative, mixes a declarative antecedent ("you love me") with an imperative consequent ("kiss me"); it is satisfied if you love and kiss me, violated if you love but don't kiss me, and avoided if you don't love me. So we need a logic of three -valued imperatives which mixes declaratives with imperatives. I develop such a logic. (shrink)

"Surrender; therefore, surrender or fight" is apparently an argument corresponding to an inference from an imperative to an imperative. Several philosophers, however (Williams 1963; Wedeking 1970; Harrison 1991; Hansen 2008), have denied that imperative inferences exist, arguing that (1) no such inferences occur in everyday life, (2) imperatives cannot be premises or conclusions of inferences because it makes no sense to say, for example, "since surrender" or "it follows that surrender or fight", and (3) distinct imperatives have conflicting permissive presuppositions (...) ("surrender or fight" permits you to fight without surrendering, but "surrender" does not), so issuing distinct imperatives amounts to changing one's mind and thus cannot be construed as making an inference. In response I argue inter alia that, on a reasonable understanding of 'inference', some everyday-life inferences do have imperatives as premises and conclusions, and that issuing imperatives with conflicting permissive presuppositions does not amount to changing one's mind. (shrink)

You may not know me well enough to evaluate me in terms of my moral character, but I take it you believe I can be evaluated: it sounds strange to say that I am indeterminate, neither good nor bad nor intermediate. Yet I argue that the claim that most people are indeterminate is the conclusion of a sound argument—the indeterminacy paradox—with two premises: (1) most people are fragmented (they would behave deplorably in many and admirably in many other situations); (2) (...) fragmentation entails indeterminacy. I support (1) by examining psychological experiments in which most participants behave deplorably (e.g., by maltreating “prisoners” in a simulated prison) or admirably (e.g., by intervening in a simulated theft). I support (2) by arguing that, according to certain plausible conceptions, character evaluations presuppose behavioral consistency (lack of fragmentation). Possible reactions to the paradox include: (a) denying that the experiments are relevant to character; (b) upholding conceptions according to which character evaluations do not presuppose consistency; (c) granting that most people are indeterminate and explaining why it appears otherwise. I defend (c) against (a) and (b). (shrink)

Critiques existing theoretical approaches and practices of philosophical counseling and presents a new model.

Why does classical equilibrium statistical mechanics work? Malament and Zabell (1980) noticed that, for ergodic dynamical systems, the unique absolutely continuous invariant probability measure is the microcanonical. Earman and Rédei (1996) replied that systems of interest are very probably not ergodic, so that absolutely continuous invariant probability measures very distant from the microcanonical exist. In response I define the generalized properties of epsilon-ergodicity and epsilon-continuity, I review computational evidence indicating that systems of interest are epsilon-ergodic, I adapt Malament and Zabell’s (...) defense of absolute continuity to support epsilon-continuity, and I prove that, for epsilon-ergodic systems, every epsilon-continuous invariant probability measure is very close to the microcanonical. (shrink)

Kadri Vihvelin, in "What time travelers cannot do" (Philos Stud 81: 315-330, 1996), argued that "no time traveler can kill the baby who in fact is her younger self, because (V1) "if someone would fail to do something, no matter how hard or how many times she tried, then she cannot do it", and (V2) if a time traveler tried to kill her baby self, she would always fail. Theodore Sider (Philos Stud 110: 115-138, 2002) criticized Vihvelin's argument, and Ira (...) Kiourti (Philos Stud 139: 343-352, 2008) criticized both Vihvelin's argument and Sider's critique. I present a critique of Vihvelin's argument different from both Sider's and Kiourti's critiques: I argue in a novel way that both V1 and V2 are false. Since Vihvelin's argument might be understood as providing a challenge to the possibility of time travel, if my critique succeeds then time travel survives such a challenge unscathed. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Wittgenstein, Tolstoy, and ShakespearePeter B. LewisNear the middle of the first of his 1938 Lectures on Aesthetics, Wittgenstein talks about what he calls "the tremendous things in art"(LC, I 23 8, italics in original).1 Apart from a brief indication of the way in which our response to the tremendous differs from the non-tremendous, he does not refer again in this way to the tremendous things in art, though he (...) does refer elsewhere to what he calls "supreme art." But he does provide a couple of examples of the tremendous in art, the symphonies of Beethoven and Gothic Cathedrals. Suppose, now, like the student in the Investigations §185, we are asked to continue the series. I take it that, even given the lack of information, we could safely propose, say, Homer—the Iliad and the Odyssey—and Michelangelo—the Sistine Chapel—as further examples of the tremendous things in art. The idea is that the tremendous things in art are not works that are just very good or very fine, but rather they are great, supremely great; works of stature; special cases; instances of the highest kind of artistic achievement, occupying a distinctive place in the history of (Western) civilization.Another obvious candidate for the list of the tremendous things in art would be Shakespeare, where the name is shorthand for the great plays, the tragedies in particular, Lear, Hamlet, Othello,and so on. So it comes as something of a surprise to discover on reading that miscellaneous compendium of remarks known as Culture and Value that Wittgenstein himself had serious doubts about including Shakespeare in the pantheon of the tremendous things in art. There are seven passages in Culture and Value in which Wittgenstein reflects on Shakespeare.2 The earliest is dated 1939–40, though this passage does not appear to be critical of Shakespeare. The next two passages are [End Page 241] dated August 1946, the remainder coming in 1949 and 1950. The remarks critical of Shakespeare are, then, all very much late Wittgenstein.It is well-known that lots of people dislike Shakespeare's plays. Generations of school children have developed indifference or boredom or hatred that persists throughout their lives. And yet that does not count against Shakespeare's greatness; for, to borrow Hume's remark on those who would prefer Ogilby to Milton, "no one pays attention to such a taste; and we pronounce without scruple the sentiment of these [people] to be absurd and ridiculous."3 That rhetoric is, however, not available, at least not immediately, when the "pretended critic" (Hume's phrase) has the intellectual clout and aesthetic sensibility of a Wittgenstein; nor, for that matter, the artistic achievement of a Tolstoy.I have particular grounds for bringing Tolstoy into this discussion. In the first place, there is the importance of Tolstoy in the development of Wittgenstein's thinking about religious, moral and aesthetic issues. Secondly, it is by contrast with Tolstoy's criticism of Shakespeare that we can gain further understanding of Wittgenstein's remarks on Shakespeare. These two points are related. For it seems to me that it is partly through his reflections on Tolstoy's theories about art that Wittgenstein is led into commenting upon Shakespeare.Tolstoy famously attacks Shakespeare in his pamphlet, "Shakespeare and the Drama,"4 published in 1903 when Tolstoy was seventy-five years of age. Some have taken this essay as evidence that Tolstoy was in his dotage, his mind warped by religious-moralistic fervor. Not only does this fail to do justice to Tolstoy's reasons for criticizing Shakespeare—reasons that Howard Mounce has recently argued are by no means ridiculous5 —it also neglects the fact that the essay is the culmination of Tolstoy's life-long antagonism to Shakespeare. Nevertheless, that very slur on Tolstoy's sanity attests to Shakespeare's status in our culture as something tremendous. His achievement is a standard against which others are measured. And this, I think, is at least partly what Wittgenstein is hinting at in his remarks about the contrast between the tremendous and the non-tremendous in art when he says of the tremendous that "it plays an entirely different role... (shrink)

According to Hempel's paradox, evidence (E) that an object is a nonblack nonraven confirms the hypothesis (H) that every raven is black. According to the standard Bayesian solution, E does confirm H but only to a minute degree. This solution relies on the almost never explicitly defended assumption that the probability of H should not be affected by evidence that an object is nonblack. I argue that this assumption is implausible, and I propose a way out for Bayesians. Introduction Hempel's (...) paradox, the standard Bayesian solution, and the disputed assumption Attempts to defend the disputed assumption Attempts to refute the disputed assumption A way out for Bayesians Conclusion. (shrink)

If time travel is possible, presumably so is my shooting my younger self ; then apparently I can kill him – I can commit retrosuicide. But if I were to kill him I would not exist to shoot him, so how can I kill him? The standard solution to this paradox understands ability as compossibility with the relevant facts and points to an equivocation about which facts are relevant: my killing YS is compossible with his proximity but not with his (...) survival, so I can kill him if facts like his survival are irrelevant but I cannot if they are relevant. I identify a lacuna in this solution, namely its reliance without argument on the hidden assumption that my killing YS is possible: if it is impossible, it is not compossible with anything. I argue that this lacuna is important, and I sketch a different solution to the paradox. (shrink)

I defend the epistemic thesis that evaluations of people in terms of their moral character as good, bad, or intermediate are almost always epistemically unjustified. (1) Because most people are fragmented (they would behave deplorably in many and admirably in many other situations), one's prior probability that any given person is fragmented should be high. (2) Because one's information about specific people does not reliably distinguish those who are fragmented from those who are not, one's posterior probability that any given (...) person is fragmented should be close to one's prior—and thus should also be high. (3) Because being fragmented entails being indeterminate (neither good nor bad nor intermediate), one's posterior probability that any given person is indeterminate should also be high—and the epistemic thesis follows. (1) and (3) rely on previous work; here I support (2) by using a mathematical result together with empirical evidence from personality psychology. (shrink)

The Principal Principle (PP) says that, for any proposition A, given any admissible evidence and the proposition that the chance of A is x%, one's conditional credence in A should be x%. Humean Supervenience (HS) claims that, among possible worlds like ours, no two differ without differing in the spacetime-point-by-spacetime-point arrangement of local properties. David Lewis (1986b, 1994a) has argued that PP contradicts HS, and the validity of his argument has been endorsed by Bigelow et al. (1993), Thau (1994), Hall (...) (1994), Strevens (1995), Ismael (1996), Hoefer (1997), and Black (1998). Against this consensus, I argue that PP might not contradict HS: Lewis's argument is invalid, and every attempt – within a broad class of attempts – to amend the argument fails. (shrink)

I outline six components of a comprehensive proposal for overhauling the foundations of deontic logic. (1) Actions and prescriptions are temporally indexed; more precisely, they attach to nodes of a tree in a branching time structure. (2) Actions are (modeled as) sets of branches and can be coarse- or fine-grained depending on whether or not they have proper subsets which are also actions. (3) Prescriptions have satisfaction and violation sets; these are sets of branches which may—but need not—be or include (...) actions. (4) Prescriptive propositions, which state that an action is obligatory/permitted/forbidden according to a given prescription, are defined by relating the action with the satisfaction and violation sets of the prescription. (5) Conditional prescriptions can—but need not—be derived from unconditional or even from other conditional ones. (6) Thick prescriptions, in contrast to thin ones, prescribe or proscribe actions with varying intensities, and can have embedded subprescriptions (some of which are negative, namely “contraryto-duty”). Most of the above components are inspired by the literature, but their combination is novel. (shrink)

David Lewis (1980) proposed the Principal Principle (PP) and a “reformulation” which later on he called ‘OP’ (Old Principle). Reacting to his belief that these principles run into trouble, Lewis (1994) concluded that they should be replaced with the New Principle (NP). This conclusion left Lewis uneasy, because he thought that an inverse form of NP is “quite messy”, whereas an inverse form of OP, namely the simple and intuitive PP, is “the key to our concept of chance”. I argue (...) that, even if OP should be discarded, PP need not be. Moreover, far from being messy, an inverse form of NP is a simple and intuitive Conditional Principle (CP). Finally, both PP and CP are special cases of a General Principle (GP); it follows that so are PP and NP, which are thus compatible rather than competing. (shrink)

Histories of science in modern China often explore their subjects within global or national frameworks. This essay uses data from gazetteers to address the place-based nature of Chinese agricultural science as it developed at smaller geographical scales. Information contained in gazetteers suggests that regional environmental knowledge and site-specific social networks influenced the construction and communication of scientific ideas about farming at the local level. By highlighting these dimensions of knowledge making, this essay demonstrates the benefits of using gazetteers to grapple (...) with the importance of place in Chinese science. (shrink)

Amit Goswami published his book, "The Self-Aware Universe: How Consciousness Creates the Material World", in 1993. In 1996, he and Henry Swift started up the online newsletter Science Within Consciousness, which carries articles and news features connected with the Goswamian philosophy. Below, I comment on Goswami 's metaphysical theories as represented in his writings in the SWC newsletter, especially in his pieces: Monistic Idealism May Provide Better Ontology for Cognitive Science: A Reply to Dyer, The Hard Question: View from A (...) Science Within Consciousness, Toward an Understanding of the Paranormal, Amit Goswami was a professor at the Institute of Theoretical Science at the University of Oregon. He taught physics for 32 years in the USA, mostly at Oregon. He now is Senior Resident Researcher at the Institute of Noetic Sciences. (shrink)

The ratio of index- and ring-finger lengths is thought to be related to prenatal androgen exposure, and in many, though not all, populations, men have a lower average digit ratio than do women. In many studies an inverse relationship has been observed, among both men and women, between 2D:4D ratio and measures of athletic ability. It has been further suggested that, in hunter-gatherer populations, 2D:4D ratio might also be negatively correlated with hunting ability, itself assumed to be contingent on athleticism. (...) This hypothesis has been tested using endurance running performance among runners from a Western, educated, and industrialized population as a proximate measure of hunting ability. However, it has not previously been tested among actual hunter-gatherers using more ecologically valid measures of hunting ability and success. The current study addresses this question among Tanzanian Hadza hunter-gatherers. I employ a novel method of assessing hunting reputation that, unlike previous methods, allows granular distinctions to be made between hunters at all levels of perceived ability. I find no statistically significant relationship between digit ratio and either hunting reputation or two important hunting skills. I confirm that Hadza men have higher mean 2D:4D ratios than men in many Western populations. I discuss the notion that 2D:4D ratio may be the consequence of an allometric scaling relationship between relative and absolute finger lengths. Although it is difficult to draw clear conclusions from these results, the current study provides no support for the theorized relationship between 2D:4D ratio and hunting skill. (shrink)

Controversies in science have a tendency to be long-lasting. Moreover, they tend to wither rather than be solved by sorting out the arguments pro and con. Barring the sociological dimension, an important factor in the perpetuation of scientific controversies seems to be the contestants' passion for broad philosophical theses when it comes to defending their respective positions. In this paper one such controversy is analysed. It involves the alleged use of Popperian falsificationism to defend a position in (community) ecology some (...) years ago. The upshot of the analysis is that falsificationism is altogether irrelevant to the controversy's solution; philosophy, though, is utterly relevant if one limits it to elementary, uncontroversial, normative methodological principles. (shrink)

Besides pure declarative arguments, whose premises and conclusions are declaratives (“you sinned shamelessly; so you sinned”), and pure imperative arguments, whose premises and conclusions are imperatives (“repent quickly; so repent”), there are mixed-premise arguments, whose premises include both imperatives and declaratives (“if you sinned, repent; you sinned; so repent”), and cross-species arguments, whose premises are declaratives and whose conclusions are imperatives (“you must repent; so repent”) or vice versa (“repent; so you can repent”). I propose a general definition of argument (...) validity: an argument is valid exactly if, necessarily, every fact that sustains its premises also sustains its conclusion, where a fact sustains an imperative exactly if it favors the satisfaction over the violation of the imperative, and a fact sustains a declarative exactly if, necessarily, the declarative is true if the fact exists. I argue that this definition yields as special cases the standard definition of validity for pure declarative arguments and my previously defended definition of validity for pure imperative arguments, and that it yields intuitively acceptable results for mixed-premise and cross-species arguments. (shrink)

A detailed discussion of issues in philosophical counseling for the practitioner and general public.

Previous research in North America has supported the view that male involvement in committed, romantic relationships is associated with lower testosterone (T) levels. Here, we test the prediction that undergraduate men involved in committed, romantic relationships (paired) will have lower T levels than men not involved in such relationships (unpaired). Further, we also test whether these differences are more apparent in samples collected later, rather than earlier, in the day. For this study, 107 undergraduate men filled out a questionnaire and (...) collected one saliva sample (from which a subject’s T level was measured) at various times across the day. As in previous studies, men involved in committed, romantic relationships had lower salivary T levels, though only during later times of the day. Furthermore, additional analysis of the variation among unpaired subjects indicated that men without prior relationship experience had lower T levels than experienced men. Finally, while paired men as a group had lower T levels than unpaired men, those men at the earliest stage (less than six months) of a current relationship had higher T levels than unpaired men as well as men in longer-term relationships. These results suggest that variation in male testosterone levels may reflect differential behavioral allocation to mating effort. (shrink)

Ever since ecology's inception, the concept of competition has generated discussion. Recent discussions have focused on the role of interspecific competition in shaping the structure of ecological communities. More in particular, ecologists are split up over the validity of a method that is currently in vogue to discredit explanations of community structure in terms of competition theory. An analysis of this controversy is presented which attempts to show that the discussions so far have focused on the wrong issues. Not the (...) method's ability to generate alternative explanations should be questioned, but its ability to generate superior explanations. The impact of Popperian philosophy of science on the dispute is briefly discussed. (shrink)

This paper investigates relationships between men’s testosterone and family life in a sample of approximately 350 Jamaican fathers of children 18–24 months of age. The study recognizes the role of testosterone as a proximate mechanism coordinating and reflecting male life history allocations within specific family and cultural contexts. A sample of Jamaican fathers and/or father figures reported to an assessment center for an interview based on a standardized questionnaire and provided a saliva sample for measuring testosterone level. Outcomes measured include (...) subject demographics such as age and relationship status as well as partnership quality and sexuality and paternal attitudes and behavior. The variation in these fathers’ relationship status (e.g., married co-residential fathers, fathers in new non-residential relationships) was not associated with men’s testosterone. Too few stepfathers participated to enable a direct test of the prediction that stepfathers would have higher testosterone than biological fathers, although fathers who reported living with partners’ (but not his own) children did not have higher testosterone than fathers not reporting residing with a non-biological child. Fathers’ relationship quality was negatively related to their testosterone. Measures of paternal attitudes and behavior were not related to fathers’ testosterone. Consistent with previous ethnography, this sample of Jamaican fathers exhibited variable life history profiles, including residential status. We discuss why fathers’ relationship quality was found to be negatively related to their testosterone level, but other predictions were not upheld. (shrink)